基本信息

书名：文昌鱼免疫系统(TheImmuneSystemofAmphioxus)(英文版)

定价：148.00元

作者：徐安龙

出版社：科学出版社

出版日期：2011-10-01

ISBN：9787030323163

字数：

页码：303

版次：1

装帧：平装

开本：16开

商品重量：0.4kg

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内容提要

《文昌鱼免疫系统（TheImmuneSystemofAmphioxus）(英文版)》是一本关于文昌鱼免疫学研究的专著。文昌鱼属于脊索动物门头索动物亚门，是现存与脊椎动物亲缘近的无脊椎动物之一，被誉为研究脊椎动物起源和演化的“活化石”，也是研究脊椎动物免疫起源与演化，特别是由天然免疫到适应性免疫的过渡的重要的模式生物。本书详细介绍了文昌鱼研究历史和文昌鱼生物学，重点从比较免疫学的视角全面介绍了文昌鱼免疫系统的研究进展，主要包括以文昌鱼为代表的头索动物天然免疫及其向脊椎动物的演化，头索动物原始适应性免疫的基本框架。本书同时向读者介绍了近年文昌鱼研究的一系列重大发现：如发现头索动物免疫大爆炸现象，文昌鱼中发现适应性免疫的标志细胞--淋巴样细胞及其信号转导的关键分子，在头索动物文昌鱼中存在外源性细胞凋亡通路等。另外，本书也分析了未来文昌鱼免疫研究的发展方向。

目录

About the Author
nForeword
nPreface
n1 Amphioxus is a model for understanding the evolutioof vertebrate
n1.1 Brief introductioof amphioxus
n1.2 Biology of amphioxus
n1.2.1 Reproductioand embryogenesis of amphioxus
n1.2.2 Anatomy of amphioxus
n1.3 The Story of amphioxus and its early researches iChina
nReferences
n2 Basic knowledge of immunology
n2.1 Immune organs
n2.1.1 Primary lymphoid organs
n2.1.2 Secondary lymphoid organs
n2.2 Immune cells
n2.2.1 Lymphoid cells
n2.2.2 Innate immunity associated cells
n2.3 Innate immunity
n2.3.1 Toll-like receptors involved signaling pathway
n2.3.2 Nod-like receptors and their functions
n2.3.3 RIG-like receptors
n2.3.4 C-type lectins
n2.3.5 The scavenger receptors
n2.3.6 Inflammation
n2.4 Adaptive immunity
n2.4.1 Specificity
n2.4.2 Diversity
n2.4.3 Immunological memory
n2.4.4 Self-nonself recognition
n2.5 Complement system
n2.5.1 Complement pathways
n2.5.2 Complement ihost defense
nReferences
n3 Immune organs and cells of amphioxus
n3.1 Introduction
n3.2 Organs of the amphioxus immune system
n3.2.1 Amphioxus gill slits:the first immune defense line
n3.2.2 Amphioxus intestine:not just a digestive orgabut also aimmune organ
n3.3 Cells of the amphioxus immune system
n3.3.1 Phagocytes
n3.3.2 Lymphocyte-like cells
nReferences
n4 Genomic and transcriptomic view of the amphioxus immunity
n4.1 Introduction
n4.2 Trace evidence of adaptive immunity
n4.2.1 TCRs, Igs and VLRs
n4.2.2 MHC and genes involved iantigepresentation
n4.3 Extraordinary gene expansioithe amphioxus innate immunity
n4.3.1 The TLR system
n4.3.2 The NLR system
n4.3.3 LRRIG proteins
n4.3.4 Other LRR-containing genes
n4.3.5 C-type lectins
n4.3.6 Scavenger receptors
n4.3.7 RIG-I-like helicases
n4.3.8 Complement-related receptors
n4.3.9 The TNF system
n4.3.10 Expansioand reshuffling of the death-fold domains
n4.3.11 Expansioof TIR adaptors, TRAFs and initiator caspases
n4.3.12 Cytokines, kinases and transcriptiofactors
n4.4 Regulatioof the amphioxus immune system
n4.4.1 Differential regulatory patterns betweeexpanded gene families
n4.4.2 The regulatioduring bacterial infection
n4.4.3 The regulatioof the terminal signaling work
n4.4.4 Differential expressiopatterns observed withiTNF and IL-1R systems
n4.4.5 Major pathways ia plex signaling work
n4.4.6 A functional prototypic plement system
n4.4.7 The prototype of oxidative burst-like system
n4.4.8 Amphioxus PGRPs and GNBPs are important effectors ithe gut
n4.4.9 Chitin-binding proteins
n4.4.10 Other effector genes
n4.5 Discussion
nReferences
n5 Patterrecognitiosystem iamphioxus
n5.1 TLR signaling pathway iamphioxus
n5.1.1 The overview
n5.1.2 TLR family iamphioxus
n5.1.3 The TIR containing adaptors iamphioxus
n5.1.4 The putative bypass pathway mediated by novel TIR adaptors
n5.1.5 The transductioand regulatioof amphioxus TLR signaling
n5.1.6 Summary
n5.2 Innate antiviral immunity iAmphioxus
n5.2.1 RLR signaling pathway
n5.2.2 Innate antiviral defense idrosophila
n5.2.3 Immune-related genes for antiviral response iamphioxus
n5.3 NLR signaling pathway
n5.3.1 NLR iamphioxus
n5.3.2 The NLR diversity iamphioxus
n5.3.3 The NLR signaling iamphioxus
nReferences
n6 Transcriptiofactors iamphioxus
n6.1 NF-κB family members iamphioxus
n6.2 The interferoregulatory factor family iamphioxus
n6.3 The STATs iamphioxus
n6.3.1 The JAK-STAT pathway
n6.3.2 The JAK-STAT pathway iinvertebrate
n6.3.3 The STAT family of mammals
n6.3.4 The structure and functioof STATs iamphioxus
n6.3.5 Evolution
nReferences
n7 The plement system of amphioxus
n7.1 Introduction
n7.2 Tracing evolutionary origiof plement system
n7.3 The plement system of amphioxus
n7.3.1 The lectipathway
n7.3.2 The alternative pathway
n7.3.3 The terminal pathway
nReferences
n8 The oxidative burst system iamphioxus
n8.1 Introduction
n8.2 NADPH Oxidases 2 and the other NOX families
n8.2.1 NOX2
n8.2.2 NOX4
n8.2.3 NOX5
n8.2.4 DUOX1 and DUOX2
n8.3 NOX Subunits and Regulatory Proteins
n8.3.1 P22phox
n8.3.2 Organizer subunit:p47phox
n8.3.3 Activator subunit:p67phox
n8.3.4 P40phox
n8.4 Functions of ROS generated by NADPH oxidases
nReferences
n9 Immune effectors iamphioxus
n9.1 Galectin
n9.2 C-type lectin
n9.3 Peptidoglycarecognitioprotein
n9.4 Gram-negative bacteria-binding protein
n9.5 Chitin-binding protein
n9.6 Apextrin
n9.7 Bactericidal/permeability-increasing protein
n9.8 Other effector genes
nReferences
n10 Lipid signaling of immune response iamphioxus
n10.1 Introduction
n10.2 The classification, structure and functioof lipids
n10.2.1 Membrane and energy storage
n10.2.2 Lipid signaling
n10.3 Origiof the vertebrate lipid signaling
n10.3.1 The origiof vertebrate eicosanoid signaling iamphioxus
n10.3.2 Conserved phospholipid signaling pathway
n10.3.3 Typical cholesterol accumulatioof inflammatioiamphioxus
n10.3.4 Downstream signaling and nuclear receptors
n10.4 Future directions
n10.5 Summary
nReferences
n11 Apoptosis iamphioxus
n11.1 General knowledge of apoptosis
n11.2 Apoptosis related gene families iamphioxus
n11.2.1 The Apaf-1 and Bcl2 homologues iamphioxus
n11.2.2 The caspase family iamphioxus
n11.2.3 The TRAIL-DR apoptosis system
n11.2.4 Perspectives:The death domaisuperfamily:a tale of two interfaces
nReferences
n12 Primitive adaptive immune system of amphioxus
n12.1 Evidence of the emergence of adaptive immunity iamphioxus
n12.1.1 Lymphocyte-like cells and related genes iamphioxus
n12.2 The primary building blocks for MHC and Rag protein
n12.2.1 Aantecedent MHC-linked genomic region
n12.2.2 The moancestor of RAG 1-and RAG 2-like genes
n12.3 The alternative forms of variable immune receptors
n12.3.1 Amphioxus candidates for adaptive immune receptors
n12.3.2 Other variable receptors iinvertebrates
nReferences
n13 Future research directions
n13.1 Ubiquitinatioof immune signaling iamphioxus
n13.1.1 Posttranslational modificatioof immune response imammals
n13.1.2 Ubiquitinatioof immune regulatioidrosophila
n13.1.3 Ubiquitinatioof immune regulatioiamphioxus
n13.2 The microRNAs iamphioxus
n13.3 Alternative 3怳TRs iamphioxus immune response
nReferences
nAbbreviatioIndex
nKey Words Index

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