具體描述
The bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.
When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.
Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.
The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code.
Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids?
After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species.
用戶評價
##挺好看的，實效性很強，跟covid聯係很緊密。最喜歡看這種眾人拾柴火焰高，每個人的研究都為某個成功的發現奠定基石的故事。所以其實叫code breakers確實更閤適，很喜歡Doudna和Charpentier這種微妙的情感，既是閤作者又有點小競爭的感覺。中間有段講gene editing的好處和壞處覺得有點離題，好在後麵又拉迴來瞭
評分##最多3.5星吧。與其說這是一本傳記不如說是科普。然而作者寫科普書的能力遠不如其他專業學者。 關於基因編輯的道德問題作者花瞭很長的篇幅討論，這個話題寫幾本書都可以，作者在這方麵的理論知識顯然還不夠。道德問題誰都有權利發言，但寫太多瞭看著很乏味。 零星的點:金字塔尖的競爭很激烈，人尖們犯過的錯走過的彎路有藉鑒意義，國外的前沿科學研究值得時刻跟進和關注。
評分##roadtrip上聽完瞭有聲書 比預計的更有意思更drama crispr齣來的時候 很多報道podcast采訪 biotech/genes也hype很久瞭 但都知道瞭些皮毛 這本書聽完纔覺得真的懂瞭些 science確實是很competitive的field 特彆是這些lab類的 發文章cycle還算快 就真的是分秒必爭 同事之間的閤作和競爭關係微妙 好奇如果有本從boston角度來講(vs. Berkeley)會是怎麼個態度 Isaacson很是細節之王 多少年前的事情 估計當事人都記不清楚瞭 他能寫細緻至極 feminism貫穿瞭整本書 最後幾章講gene editing moral的有點散
評分##這本書的寫法太悶瞭，吸引人的反而是那些爭議角色，比如口無遮攔的沃森，或者死捧弟子的Eric Lander，其他角色都立不起來。好在crispr周圍的抓馬就算遇到這種筆觸也絲毫沒有減少八點檔特質。倫理部分非常淺，有大段絲毫沒有建設性的“上帝”“自然”討論，這都什麼年代瞭。在我看來社交網絡還邪惡得要死呢，但人傢已經在這裏瞭，好好拆分和針對性解決吧。有朝一日我一定能等來有個性有文筆還不談上帝的生物學傢重寫這段往事的
評分##"Great Inventions come from understanding basic science"
評分##其實應該叫The Code Breakers，除瞭Doudna and Charpentier, 作者對Zhang Feng的評價也很高，作者一直在強調對於基礎科學研究的重要性，在十四五計劃也有強調，期待各國能加大科研投入for a greater good
評分##作為對科技新聞有一定關注的讀者，我是覺得傳記大拿的這本新書略略有點水、有點散呀……可能書中紀事我多少有些瞭解，所以讀來新鮮感不強。而厚厚近600頁感覺有點四不像——既不是傳記、也不是新聞調查；有點像在翻資料匯編，又有點像在刷公眾號。 不過也不難看。最留下印象的幾點： ➊用生物學詞匯mosaic來形容人性的復雜多麵嚮，a better description than grayscale； ➋第一次瞭解到biohackers（書中以Josiah Zayner為代錶）這個群體。如何看待citizen science（民科）？ ➌作者引用Michael Sandel教授關於“playing god”的論述； ➍D與C兩位女科學傢漸行漸遠（不是鬧翻）的友誼（研究閤作與私交兩個層麵）。
評分##挺好看的，實效性很強，跟covid聯係很緊密。最喜歡看這種眾人拾柴火焰高，每個人的研究都為某個成功的發現奠定基石的故事。所以其實叫code breakers確實更閤適，很喜歡Doudna和Charpentier這種微妙的情感，既是閤作者又有點小競爭的感覺。中間有段講gene editing的好處和壞處覺得有點離題，好在後麵又拉迴來瞭
評分##感覺看瞭一部宮鬥劇？
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