具体描述
The bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.
When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.
Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.
The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code.
Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids?
After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species.
用户评价
##作为对科技新闻有一定关注的读者，我是觉得传记大拿的这本新书略略有点水、有点散呀……可能书中纪事我多少有些了解，所以读来新鲜感不强。而厚厚近600页感觉有点四不像——既不是传记、也不是新闻调查；有点像在翻资料汇编，又有点像在刷公众号。 不过也不难看。最留下印象的几点： ➊用生物学词汇mosaic来形容人性的复杂多面向，a better description than grayscale； ➋第一次了解到biohackers（书中以Josiah Zayner为代表）这个群体。如何看待citizen science（民科）？ ➌作者引用Michael Sandel教授关于“playing god”的论述； ➍D与C两位女科学家渐行渐远（不是闹翻）的友谊（研究合作与私交两个层面）。
评分##读了Emmanuelle Charpentier, Feng Zhang, &He jiankui, CRISPR, Gene editing historic records部分，作者写到science内容一笔带过，想了解详细内容自己去看文献，历史的部分讲述得比较精彩，不搞学术的人读了能看到研究进步发展时间线上科学家们的主导、参与、被遗忘、被放弃及存活的真实展现，good read
评分##除了学习科学知识 还借鉴得到成功科学家的品质 追求卓越注重合作然而又能严格管理自己的时间界限 生命科学的魅力 疫情初期紧锣密鼓的研究与疫苗开发 意外还有1984 vs. Brave New World这一对比重现 虽然有主POV CRISPR学术之争的叙述个人感觉尚且公正 希望能多收集一些行家线报实验室风云!
评分##感觉看了一部宫斗剧？
评分##很精彩的故事，高尖端的科技，科学家的争名夺利，关于道德的争论，都很有意思，不过感觉作者夹带私货略多
评分侦探小说一样，好看的简直停不下来，比前一步著作 达芬奇 好看的多，读达芬奇的时候 一直瞌睡。这本书简直停不下来。微积分的发现，大家争来争去，DNA结构的发现，大家争来争去，人类基因组计划，大家争来争去， crisper-cas9,大家争来争去。其实你发现没有，个人的贡献是有限的，没有谁，地球照样转。科学的发现和进步，是一个水到渠成，成千上万的人一步一步做出来的，个人的贡献往往被放大，而更多的人则被忽略。感觉Jennifer是一个很爱抢功劳的人，也许是中国人都zhangfeng有同情。不过她的合作者都疏远了她。鸡血的中国妈妈可以看看，美国也有尖子班，张峰也上补习班的，不过他上的是将荧光蛋白重组表达的相关工作。最不喜欢书里面的thought experiment, 是这本书最大的败笔
评分##这本书的写法太闷了，吸引人的反而是那些争议角色，比如口无遮拦的沃森，或者死捧弟子的Eric Lander，其他角色都立不起来。好在crispr周围的抓马就算遇到这种笔触也丝毫没有减少八点档特质。伦理部分非常浅，有大段丝毫没有建设性的“上帝”“自然”讨论，这都什么年代了。在我看来社交网络还邪恶得要死呢，但人家已经在这里了，好好拆分和针对性解决吧。有朝一日我一定能等来有个性有文笔还不谈上帝的生物学家重写这段往事的
评分侦探小说一样，好看的简直停不下来，比前一步著作 达芬奇 好看的多，读达芬奇的时候 一直瞌睡。这本书简直停不下来。微积分的发现，大家争来争去，DNA结构的发现，大家争来争去，人类基因组计划，大家争来争去， crisper-cas9,大家争来争去。其实你发现没有，个人的贡献是有限的，没有谁，地球照样转。科学的发现和进步，是一个水到渠成，成千上万的人一步一步做出来的，个人的贡献往往被放大，而更多的人则被忽略。感觉Jennifer是一个很爱抢功劳的人，也许是中国人都zhangfeng有同情。不过她的合作者都疏远了她。鸡血的中国妈妈可以看看，美国也有尖子班，张峰也上补习班的，不过他上的是将荧光蛋白重组表达的相关工作。最不喜欢书里面的thought experiment, 是这本书最大的败笔
评分##感觉看了一部宫斗剧？
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