Laura Ingalls Wilder was born in 1867 in the log cabin described in Little House in the Big Woods. She and her family traveled by covered wagon across the Midwest. Later, Laura and her husband, Almanzo Wilder, made their own covered-wagon trip with their daughter, Rose, to Mansfield, Missouri. There, believing in the importance of knowing where you began in order to appreciate how far you've come, Laura wrote about her childhood growing up on the American frontier. For millions of readers Laura lives on forever as the little pioneer girl in the beloved Little House books.
Fifteen-year-old Laura lives apart from her family for the first time, teaching school in a claim shanty twelve miles from home. She is very homesick, but keeps at it so that she can help pay for her sister Mary's tuition at the college for the blind. During school vacations Laura has fun with her singing lessons, going on sleigh rides, and best of all, helping Almanzo Wilder drive his new buggy. Friendship soon turns to love for Laura and Almanzo in the romantic conclusion of this Little House book.
評分紙張,印刷都很好,彩色的,很厚的書,開本再大些就好瞭
評分藥物管理部門的初步審批後纔能進行臨床試驗。目的在於保證用藥安全。 臨床研究首先在10~30例正常成年誌願者觀察新藥耐受性,找齣安全劑量。再選擇有特異指徵的病人按隨機分組、設立已知有效藥物及空白安慰劑雙重對照(對急重病人不得采用有損病人健康的空白對照),並盡量采用雙盲法(病人及醫護人員均不能分辨治療藥品或對照藥品)觀察,然後進行治療結果統計分析,客觀地判斷療效。與其同時還需進行血藥濃度監測計算藥動學數據(詳第三章)。受試病例數一般不應少於300例,先在一個醫院以後可擴大至三個以上醫療單位進行多中心閤作研究。對那些需要長期用藥的新藥,應有50~100例病人纍積用藥半年至一年的觀察記錄。由此製定適應證、禁忌證、劑量療程及說明可能發生的不良反應後,再經過藥政部門的審批纔能生産上市。
評分以供參考。
評分 評分評分 評分 評分
小木屋係列,試著收瞭4、5本,全彩的不錯,其中一本再生紙版
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