編輯推薦

　　經典名著 《Williams血液學》是血液學領域公認的經典之作，經過多次修訂，指導瞭一代又一代的臨床醫生、生物學研究者和眾多學科的實習生。作者們均是各自領域的學術帶頭人，他們的基礎和臨床成果得到瞭國際廣泛認可。

　　內容全麵 共139章，涵蓋瞭血液學的所有方麵。前半部分討論瞭患者臨床評估、血液病的分子學和細胞學基礎，後半部分具體闡述瞭紅細胞疾病、粒細胞和單核細胞疾病、淋巴細胞和漿細胞疾病、髓係腫瘤性疾病、淋巴組織疾病、止血和血栓，以及輸血醫學。包含彩圖1300餘幅。

　　與時俱進 《Williams血液學（第9版）》在基礎科學、轉換病理生理學和臨床實踐方麵做瞭大篇幅的修改和更新，以反映血液學領域蕞新的研究進展。

　　印刷精美 全書彩色印刷，包含大量極具診斷價值的細胞形態學圖片，使閱讀和查找更加直觀、方便。

內容簡介

　　《Williams血液學》是血液學領域的經典之作，涵蓋瞭血液學的所有方麵，介紹瞭患者臨床評估、血液病的分子學和細胞學基礎，並具體闡述瞭紅細胞疾病、粒細胞和單核細胞疾病、淋巴細胞和漿細胞疾病、髓係腫瘤性疾病、淋巴組織疾病、止血和血栓、輸血醫學等內容。第9版在第8版的基礎上做瞭大篇幅的修改和更新，以反映血液學領域的蕞新進展。新增加瞭錶觀遺傳學和基因組學、血液腫瘤細胞的新陳代謝和肝素誘導性血小闆減少癥等內容。本書是血液科臨床醫生、實習生、血液學研究人員必不可少的案頭佳作，也是學習血液學專業英語的工具書。

作者簡介

　　考杉斯基（Kaushansky）博士是紐約州立大學石溪分校健康科學院的高級副總裁，同時擔任該校醫學院院長的職務。考杉斯基（Kaushansky）博士是全球知名的血液學專傢，發錶過多篇有影響力的著作。擔任《Willians血液學》第8版、第9版的主編。

內頁插圖

目錄

Contributors

Preface

PART IClinical Evaluation of the Patient

PARTII TheOrganization of the LymphohematopoieticTissues

PARTIII EpochalHematology

PARTIV Molecular and CellularHematology

PARTV TherapeuticPrinciples

PARTVI The Erythrocyte

PARTVII Neutrophils,Eosinophils,Basophils, and Mast Cells

PARTVIII Monocytes and Macrophages

PARTIX Lymphocytes and Plasma Cells

PARTX MalignantMyeloid Diseases

PARTXI MalignantLymphoid Diseases

PARTXII Hemostasis andThrombosis

PARTXIII Transfusion Medicine

Index

前言/序言

　　The first edition of Williams Hematology (né Hematology) was publishedin 1972. This, our 9th edition, will represent our continued efforts over nearly one-half century to provide the most current concepts of the pathophysiology and treatment of hematologic diseases.

　　The rate of growth in our understanding of diseases of blood cells and coagulation pathways provides a challenge for editors of a comprehensive textbook of hematology. The sequencing of individual genomes, analysis of the “dark DNA” and noncoding RNAs, advances in knowledge in proteomics, metabolomics, and other “-omics” fields, as applied to hematologic disorders, have accelerated the understanding of the pathogenesis of the diseases of our interest. The rate at which basic knowledge in molecular and cellular biology and immunology has been translated into improved diagnostic and therapeutic methods is equally impressive. Specific molecular targets for therapy in several hematologic disorders have become reality, and it is not hyperbole to state that hematology is the poster child for the rational design of therapeutics applicable to other fields of medicine.

　　This edition of Williams Hematology includes changes designed tofacilitate ease of access to information, both within the book and its associated links, and has been modestly reorganized to reflect our greater understanding of the origins of hematologic disorders. Each chapter has been revised or rewritten to provide current information. Four new chapters have been added and other notable changes have been made. Chapter 4 “Consultative Hematology” is new to this edition. The chapter “Epigenetics and Genomics” has been divided into separate chapters to reflect the growth of knowledge in those disciplines. Chapter 14, “Metabolism of Hematologic Neoplastic Cells” is new, as this topic has become the basis of multiple potential drug targets for hematologic disease. A section on “Autophagy” has been added to Chap 15 “Apoptosis Mechanisms: Relevance to the Hematopoietic System,” as the topic is becoming increasingly important for understanding of the physiology of blood cell development; and an independent chapter “Heparin-Induced Thrombocytopenia” (Chap 118) has been created to reflect both its pathophysiologic and clinical importance. Recognizing that at the heart of diagnostic hematology is blood and marrow cell morphology, we have continued our incorporation of informative color images of the relevant disease topics in each chapter, allowing easy access to illustrations of cell morphology important to diagnosis.

　　The 9th edition of Williams Hematology is also available online,as part of the excellent www.accessmedicine.com website. With direct links to a comprehensive drug therapy database and to other important medical texts, including Harrison’s Principles of Internal Medicine and Goodman and Gilman’sof Williams Hematology also includes PubMed links to journal articlescited in the references.

　　In addition, Williams Manual of Hematology will be revised to reflect the diagnostic and therapeutic advances incorporated in the 9th edition of Williams Hematology. The convenient Manual features the most clinically salient content from the parent text, and is useful in time-restricted clinical situations. The Manual will be available for iPhone? and other mobile formats.

　　The readers of the 9th edition of Williams Hematology will note a“changing of (some of) the guard” of our editorial group; Drs. Marcel Levi (a member of the 8th edition of Williams Manual of Hematology editorial group), Oliver Press, Linda Burns, and Michael Caligiuri have joined continuing editors Drs. Kenneth Kaushansky, Marshall Lichtman, and Josef Prchal in the 9th edition.

　　The production of this book required the timely cooperation of 101 contributors for the production of 139 chapters. We are grateful for their work in providing this comprehensive and up-to-date text. Despite the growth of both basic and clinical knowledge and the passion that each of our contributors brings to the topic of their chapter, we have been able to maintain the text in a single volume through scrupulous attention to chapter length.

　　Each editor has had expert administrative assistance in the management of the manuscripts for which they were primarily responsible. We thank Susan Madden in Salt Lake City, Utah; Nancy Press and Deborah Lemon in Seattle, Washington; and Annie Thompson, Rebecca Posey, and Kimberly Morley in Columbus, Ohio for their very helpful participation in the production of the book. Special thanks go to Susan Daley in Rochester, New York, and Marie Brito in Stony Brook, New York, who were responsible for coordinating the management of 139 chapters, including many new figures and tables, and managing other administrative matters, a challenging task that Ms. Daley and Ms. Brito performed with skill and good humor.

　　Kenneth Kaushansky

　　Marshall A. Lichtman Joseph T. Prchal

　　Marcel Levi

　　Oliver W. Press

　　Linda J. Burns