The Code Breaker pdf epub mobi txt 电子书 下载 2025

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The Code Breaker

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Walter Isaacson



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发表于2025-01-11

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Simon & Schuster 2021-3-9 Hardcover 9781982115852

The Code Breaker epub 下载 mobi 下载 pdf 下载 txt 电子书 下载 2025

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The Code Breaker epub 下载 mobi 下载 pdf 下载 txt 电子书 下载 2025

The Code Breaker pdf epub mobi txt 电子书 下载



具体描述

Walter Isaacson, a professor of history at Tulane, has been CEO of the Aspen Institute, chair of CNN, and editor of Time. He is the author of Leonardo da Vinci; The Innovators; Steve Jobs; Einstein: His Life and Universe; Benjamin Franklin: An American Life; and Kissinger: A Biography, and the coauthor of The Wise Men: Six Friends and the World They Made. Visit him at Isaacson.Tulane.edu.

The bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.

When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.

Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.

The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code.

Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids?

After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species.

The Code Breaker 电子书 下载 mobi epub pdf txt

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用户评价

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##这本书的写法太闷了,吸引人的反而是那些争议角色,比如口无遮拦的沃森,或者死捧弟子的Eric Lander,其他角色都立不起来。好在crispr周围的抓马就算遇到这种笔触也丝毫没有减少八点档特质。伦理部分非常浅,有大段丝毫没有建设性的“上帝”“自然”讨论,这都什么年代了。在我看来社交网络还邪恶得要死呢,但人家已经在这里了,好好拆分和针对性解决吧。有朝一日我一定能等来有个性有文笔还不谈上帝的生物学家重写这段往事的

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##A bit all over the place, but enligtening and informative. I'm learning things I didn't know and I thoroughly enjoyed the chapters where Issacson explored the ethical issues surrounding gene editing.

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##作为对科技新闻有一定关注的读者,我是觉得传记大拿的这本新书略略有点水、有点散呀……可能书中纪事我多少有些了解,所以读来新鲜感不强。而厚厚近600页感觉有点四不像——既不是传记、也不是新闻调查;有点像在翻资料汇编,又有点像在刷公众号。 不过也不难看。最留下印象的几点: ➊用生物学词汇mosaic来形容人性的复杂多面向,a better description than grayscale; ➋第一次了解到biohackers(书中以Josiah Zayner为代表)这个群体。如何看待citizen science(民科)? ➌作者引用Michael Sandel教授关于“playing god”的论述; ➍D与C两位女科学家渐行渐远(不是闹翻)的友谊(研究合作与私交两个层面)。

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##这本书主要围绕Jennifer Doudna, 回顾了CRISPR和基因编辑的探讨. 写的跌宕起伏, 描述了科学研究者之间秘密竞争同时又对自然保护好奇心展开合作. 不同的研究者展示了非常不一样的个性. 后面几章讨论bioethics 和人类基因改造, 我不大喜欢. 作者自己个人想法太多,觉得有点肤浅, ...  

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##很难评价,还是不打分了。作者很明显是高质量传记作者,他的能力已经在乔布斯传当中充分展现了,在这本书当中更是展露无疑。science部分不难理解,但是这个作者显然是使用语言的天才。他是Doudna的传记作者,自然是非常天生地需要站在她的那一边。他采用的并非第三方的视角,去“客观”地记录CRISPR的历史。很多事件的发生过程,作者明明有相当大的篇幅可以详细地描述,反而实际上闪烁其词,直接跳到事件发生的那个时刻。但是倒有足够的空间来全文引述一篇新年的email。那一段文字显然效果很好,讽刺效果max,真是骂人于无形。 who tells the story还挺重要的,Lander在cell上的文章是这个目的,这本书同样是这个目的。心潮澎湃大可不必,不过的确是一个励志故事。 作者以2020年诺贝尔化学奖得主Jennifer Doudna为主线,讲解了基因编辑技术的发展过程,以及对当下和未来的影响,并将众多研究者饱满地呈现出来。科学知识与人物故事交织在一起,非常精彩的一本书。 作者从19世纪的达尔文和孟德尔,讲到DNA结构被发现,再到人类基因组计划。众多...  

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1、 根据我目前的认知,大部分生命活动的调控是精细而复杂的,并非敲除或改变一段序列就能产生显著效果。生命系统的复杂性也预示任意改造一段序列可能会有意外后果。此外,脱靶效应也会限制基因编辑技术的人体应用。所以,大规模的基因设计短时期内还只是个愿景,但早早开始考...  

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